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Dolan, Mary Eileen

One or more keywords matched the following properties of Dolan, Mary Eileen

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overview	The Dolan lab is focused on improving the quality of life of cancer patients through the identification of genetic variants associated with risk for severe and persistent toxicities following chemotherapy (i.e. peripheral neuropathy, ototoxicity, tinnitus), particularly in children and young adults whose adverse sequelae could persist throughout their lifetimes. To this end, they perform clinical genome wide association studies to identify genetic variants associated with toxicity in patients following chemotherapy and determine whether there is shared genetic architecture with idiopathic forms of these traits. They develop preclinical models to elucidate the biochemical and cellular impact of genes identified in clinical studies of chemotherapeutic toxicity. Their approach integrates multiple large datasets including: genetic variation, gene expression, miRNA, modified cytosine, transcription factor levels and chemotherapeutic induced pharmacologic traits. Her laboratory made the seminal observation that chemotherapeutic-induced cytotoxicity is a heritable trait and that pharmacologic SNPs, identified through GWAS, are enriched in expression quantitative trait loci. More recently, her laboratory has developed an induced pluripotent stem cell derived neuronal cell model to evaluate genes contributing to chemotherapeutic-induced neuropathy, a common adverse event of multiple chemotherapeutic agents. They are creating a resource of human induced pluripotent stem cell derived neurons from well-phenotyped cancer survivors following treatment with paclitaxel, vincristine or cisplatin to be used to identify an in vitro toxicity readout that parallels the clinical phenotype. The models they are developing will have broad applicability for gaining insight on druggable targets to treat or prevent this devastating side effect of chemotherapy and providing an understanding of the genetic components and genes contributing to severe toxicity.

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Value

overview

The Dolan lab is focused on improving the quality of life of cancer patients through the identification of genetic variants associated with risk for severe and persistent toxicities following chemotherapy (i.e. peripheral neuropathy, ototoxicity, tinnitus), particularly in children and young adults whose adverse sequelae could persist throughout their lifetimes. To this end, they perform clinical genome wide association studies to identify genetic variants associated with toxicity in patients following chemotherapy and determine whether there is shared genetic architecture with idiopathic forms of these traits. They develop preclinical models to elucidate the biochemical and cellular impact of genes identified in clinical studies of chemotherapeutic toxicity. Their approach integrates multiple large datasets including: genetic variation, gene expression, miRNA, modified cytosine, transcription factor levels and chemotherapeutic induced pharmacologic traits. Her laboratory made the seminal observation that chemotherapeutic-induced cytotoxicity is a heritable trait and that pharmacologic SNPs, identified through GWAS, are enriched in expression quantitative trait loci. More recently, her laboratory has developed an induced pluripotent stem cell derived neuronal cell model to evaluate genes contributing to chemotherapeutic-induced neuropathy, a common adverse event of multiple chemotherapeutic agents. They are creating a resource of human induced pluripotent stem cell derived neurons from well-phenotyped cancer survivors following treatment with paclitaxel, vincristine or cisplatin to be used to identify an in vitro toxicity readout that parallels the clinical phenotype. The models they are developing will have broad applicability for gaining insight on druggable targets to treat or prevent this devastating side effect of chemotherapy and providing an understanding of the genetic components and genes contributing to severe toxicity.

One or more keywords matched the following items that are connected to Dolan, Mary Eileen

Item Type	Name
Concept	Aged, 80 and over
Concept	Alkylation
Concept	Audiometry, Pure-Tone
Concept	Adolescent
Concept	Adenine Nucleotides
Concept	Adjuvants, Pharmaceutic
Concept	Aged
Concept	Biotransformation
Concept	Amino Acid Sequence
Concept	Adenosine Triphosphate
Concept	Administration, Oral
Concept	Adult
Concept	Aryl Hydrocarbon Hydroxylases
Concept	B-Lymphocytes
Concept	Base Sequence
Concept	Benzimidazoles
Concept	Biological Availability
Concept	Carmustine
Concept	Bayes Theorem
Concept	DNA Damage
Concept	DNA Polymerase II
Concept	Azacitidine
Concept	Astrocytoma
Concept	Bilirubin
Concept	Bleomycin
Concept	Body Weight
Concept	Cattle
Concept	Child
Concept	Cell Transformation, Viral
Concept	Cerebellar Neoplasms
Concept	Floxuridine
Concept	Cell Transformation, Neoplastic
Concept	Cisplatin
Concept	Leucovorin
Concept	Glutathione Peroxidase
Concept	Cricetulus
Concept	Hydroxylation
Concept	DNA-Binding Proteins
Concept	Deoxycytidine Kinase
Concept	Drug Synergism
Concept	Diet
Concept	Cytochrome P-450 Enzyme System
Concept	DNA Polymerase I
Concept	DNA Repair
Concept	Child, Preschool
Concept	DNA Mutational Analysis
Concept	DNA, Neoplasm
Concept	Cyclophosphamide
Concept	Daunorubicin
Concept	Ferredoxin-NADP Reductase
Concept	Etoposide
Concept	Cytarabine
Concept	Dimethylnitrosamine
Concept	Disease Susceptibility
Concept	DNA
Concept	DNA Topoisomerases, Type II
Concept	Drug Interactions
Concept	Drug Resistance
Concept	Inactivation, Metabolic
Concept	Indoles
Concept	Infant, Newborn
Concept	Methyltransferases
Concept	Microtubule-Associated Proteins
Concept	Fluorouracil
Concept	Deoxyadenosines
Concept	Deoxyguanosine
Concept	NAD+ Nucleosidase
Concept	Glioma
Concept	Glioblastoma
Concept	Obesity
Concept	Oncogenes
Concept	Dose-Response Relationship, Drug
Concept	Drug Labeling
Concept	Liver Neoplasms
Concept	Enzyme-Linked Immunosorbent Assay
Concept	Herpesvirus 4, Human
Concept	Escherichia coli
Concept	Flow Cytometry
Concept	Infant
Concept	Isoelectric Focusing
Concept	Genetics, Medical
Concept	Genetics, Population
Concept	Glutathione
Concept	Leukocytes, Mononuclear
Concept	Methylnitrosourea
Concept	Carcinoma, Hepatocellular
Concept	Mice, Inbred Strains
Concept	Mitoguazone
Concept	Pharmacogenetics
Concept	Phosphoramide Mustards
Concept	Pilot Projects
Concept	Macaca mulatta
Concept	Mammals
Concept	Naphthoquinones
Concept	Methylnitronitrosoguanidine
Concept	Mice, Transgenic
Concept	Neoplasm Transplantation
Concept	Immunohistochemistry
Concept	Organ Size
Concept	Organoplatinum Compounds
Concept	Molecular Sequence Data
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C57BL
Concept	Mice, Nude
Concept	Middle Aged
Concept	Random Allocation
Concept	Mycosis Fungoides
Concept	Cricetinae
Concept	Hot Temperature
Concept	Rhabdomyosarcoma
Concept	RNA Precursors
Concept	Interleukin-3
Concept	Nitrosourea Compounds
Concept	Neurons
Concept	Leukemia L1210
Concept	Ovarian Neoplasms
Concept	Ovary
Concept	Oxidation-Reduction
Concept	Oxidoreductases
Concept	Liver
Concept	Lomustine
Concept	Luciferases
Concept	Ornithine Decarboxylase
Concept	Peripheral Nervous System Diseases
Concept	Medulloblastoma
Concept	Melphalan
Concept	Sex Characteristics
Concept	Sezary Syndrome
Concept	Mesylates
Concept	Speech Reception Threshold Test
Concept	Nitrosamines
Concept	Poly T
Concept	Phenobarbital
Concept	Population Surveillance
Concept	Preoperative Care
Concept	Prostatic Neoplasms
Concept	Protein-Tyrosine Kinases
Concept	Protein-Arginine N-Methyltransferases
Concept	Forecasting
Concept	Genetic Markers
Concept	Glutamates
Concept	Idoxuridine
Concept	Rats, Inbred F344
Concept	Regression Analysis
Concept	Guanine
Concept	Risk Factors
Concept	Protein Kinases
Concept	Purines
Concept	Rats, Nude
Concept	Salmonella typhimurium
Concept	Risk
Concept	Semustine
Concept	Swine
Concept	Tachycardia, Supraventricular
Concept	Thymidine
Concept	Histones
Concept	Humans
Concept	Body Mass Index
Concept	Linear Models
Concept	Tretinoin
Concept	Software
Concept	Tetrahydrofolates
Concept	Thermodynamics
Concept	United States Food and Drug Administration
Concept	Ketoconazole
Concept	Universities
Concept	Rhabdomyosarcoma, Alveolar
Concept	Oncogene Proteins, Fusion
Concept	Risk Assessment
Concept	DNA Adducts
Concept	Drug Resistance, Neoplasm
Concept	Reverse Transcriptase Polymerase Chain Reaction
Concept	Caspases
Concept	Vinca Alkaloids
Concept	Carboplatin
Concept	Transforming Growth Factor beta
Concept	NF-kappa B
Concept	Central Nervous System Neoplasms
Concept	Myosin Type II
Concept	DNA Modification Methylases
Concept	Metabolic Clearance Rate
Concept	Neoplasms, Second Primary
Concept	Activin Receptors, Type I
Concept	Antimutagenic Agents
Concept	Lymph Nodes
Concept	CD4-Positive T-Lymphocytes
Concept	Rats, Sprague-Dawley
Concept	Sequence Analysis, DNA
Concept	Melanoma
Concept	Methionine
Concept	Methylation
Concept	Treatment Outcome
Concept	Neoplasm Metastasis
Concept	Neoplasm Recurrence, Local
Concept	Neoplasms, Experimental
Concept	Dihydrouracil Dehydrogenase (NADP)
Concept	Oligodeoxyribonucleotides
Concept	Neurites
Concept	RNA-Binding Proteins
Concept	Interferon-alpha
Concept	Gliosarcoma
Concept	Mice, Knockout
Concept	DNA, Complementary
Concept	Disease Progression
Concept	Apoptosis Regulatory Proteins
Concept	Hepatocyte Nuclear Factor 1-alpha
Concept	Simvastatin
Concept	Caspase 3
Concept	Base Pair Mismatch
Concept	Neurofibromin 1
Concept	Oxazines
Concept	Myosin Heavy Chains
Concept	Fluorescent Antibody Technique, Indirect
Concept	Cladribine
Concept	Protein Structure, Secondary
Concept	Oxygenases
Concept	Gene-Environment Interaction
Concept	Population Groups
Concept	DNA Repair Enzymes
Concept	Systems Biology
Concept	Geographic Information Systems
Concept	Proteomics
Concept	Methylenetetrahydrofolate Reductase (NADPH2)
Concept	Cortactin
Concept	Proto-Oncogene Proteins c-bcl-2
Concept	Area Under Curve
Concept	Proto-Oncogene Proteins B-raf
Concept	Caspase 1
Concept	Anthracyclines
Concept	Oligonucleotide Array Sequence Analysis
Concept	Stem Cell Factor
Concept	Caspase 12
Concept	Evidence-Based Medicine
Concept	bcl-X Protein
Concept	Peroxidases
Concept	Phenanthridines
Concept	Plasma
Concept	Platinum
Concept	Polydeoxyribonucleotides
Concept	Polyethylene Glycols
Concept	Prodrugs
Concept	Promoter Regions, Genetic
Concept	Mice
Concept	Protein Kinase C
Concept	Rats, Inbred Strains
Concept	RNA, Ribosomal, 16S
Concept	Saccharomyces cerevisiae
Concept	DNA Breaks, Double-Stranded
Concept	Research Design
Concept	Protein Phosphatase 1
Concept	Structure-Activity Relationship
Concept	DNA Glycosylases
Concept	Biomedical Research
Concept	Thrombopoietin
Concept	Tinnitus
Concept	Tissue Distribution
Concept	Rats
Concept	ADP-ribosyl Cyclase 1
Concept	Real-Time Polymerase Chain Reaction
Concept	Uracil
Concept	Stereoisomerism
Concept	Streptozocin
Concept	Vincristine
Concept	Adaptor Proteins, Signal Transducing
Concept	Blotting, Western
Concept	MutS Homolog 2 Protein
Concept	DNA Copy Number Variations
Concept	Open Reading Frames
Concept	Electronic Health Records
Concept	Transcription Factor RelA
Concept	Benzophenanthridines
Concept	Tubulin
Concept	Vinblastine
Concept	Xanthenes
Concept	Reproducibility of Results
Concept	Interleukin-11
Concept	Survival Rate
Concept	Rhabdomyosarcoma, Embryonal
Concept	Odds Ratio
Concept	Polymerase Chain Reaction
Concept	Granulocyte Colony-Stimulating Factor
Concept	Patient Selection
Concept	Receptor, ErbB-2
Concept	Lymphoma, Large B-Cell, Diffuse
Concept	Proliferating Cell Nuclear Antigen
Concept	Cyclin-Dependent Kinases
Concept	DNA Methylation
Concept	Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept	Mitogen-Activated Protein Kinase 1
Concept	Xenograft Model Antitumor Assays
Concept	Drug Resistance, Multiple
Concept	Cytochrome P-450 CYP1A2
Concept	O(6)-Methylguanine-DNA Methyltransferase
Concept	Inhibitory Concentration 50
Concept	ADP-ribosyl Cyclase
Concept	Tumor Suppressor Proteins
Concept	Organic Anion Transporters
Concept	DEAD-box RNA Helicases
Concept	DNA Mismatch Repair
Concept	Genome-Wide Association Study
Concept	Precision Medicine
Concept	RNA, Small Interfering
Concept	Molecular Sequence Annotation
Concept	CDC2-CDC28 Kinases
Concept	Hand-Foot Syndrome
Concept	Intracellular Signaling Peptides and Proteins
Concept	GATA3 Transcription Factor
Concept	Cytochrome P-450 CYP3A
Concept	Proto-Oncogene Proteins c-bcr
Concept	Myeloid-Lymphoid Leukemia Protein
Concept	Kaplan-Meier Estimate
Concept	Drug Discovery
Concept	RNA Isoforms
Concept	Aldehyde Dehydrogenase
Concept	Antibodies
Concept	Brain Neoplasms
Concept	Chlorambucil
Concept	Chromatin
Concept	Colistin
Concept	Cytosine
Concept	Deoxycytidine
Concept	Diethylnitrosamine
Concept	Dimethylhydrazines
Concept	DNA, Single-Stranded
Concept	Doxorubicin
Concept	Electrochemistry
Concept	Ethylnitrosourea
Concept	Folic Acid
Concept	Ifosfamide
Concept	Leukemia P388
Concept	Lymphocytes
Concept	Mice, Mutant Strains
Concept	Plicamycin
Concept	Models, Neurological
Concept	Monocytes
Concept	Neuroblastoma
Concept	Organ Specificity
Concept	Peptides
Concept	Phenotype
Concept	Polyneuropathies
Concept	Population
Concept	Predictive Value of Tests
Concept	Procarbazine
Concept	Prospective Studies
Concept	Ribonucleoside Diphosphate Reductase
Concept	RNA, Ribosomal
Concept	Speech
Concept	Thymine
Concept	Thymus Gland
Concept	Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept	5'-Nucleotidase
Concept	Tumor Suppressor Protein p53
Concept	Granulocyte-Macrophage Colony-Stimulating Factor
Concept	Anticarcinogenic Agents
Concept	Mitomycin
Concept	Ribonucleoproteins, Small Nuclear
Concept	Age of Onset
Concept	DNA Primers
Concept	Hyaluronan Receptors
Concept	Computational Biology
Concept	Genetic Predisposition to Disease
Concept	Maximum Tolerated Dose
Concept	Genomics
Concept	Databases, Nucleic Acid
Concept	MicroRNAs
Concept	Semaphorins
Concept	Protein Array Analysis
Concept	Chromosomes, Human, X
Concept	Cyclin-Dependent Kinase 2
Concept	Transcription Factor CHOP
Concept	Caspase 9
Concept	Glypicans
Concept	Young Adult
Concept	HapMap Project
Academic Article	5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Academic Article	Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
Academic Article	Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.
Academic Article	Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article	Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
Academic Article	Peripheral blood mononuclear cell dihydropyrimidine dehydrogenase activity in volunteers with and without diabetes mellitus.
Academic Article	Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer.
Academic Article	O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
Academic Article	Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
Academic Article	Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.
Academic Article	Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.
Academic Article	Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer.
Academic Article	Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
Academic Article	Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
Academic Article	O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
Academic Article	Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.
Academic Article	Determination of 8-oxoguanine in human plasma and urine by high-performance liquid chromatography with electrochemical detection.
Academic Article	Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer.
Academic Article	Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases.
Academic Article	Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation.
Academic Article	O6-benzylguanine and its role in chemotherapy.
Academic Article	Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
Academic Article	Role of O6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity.
Academic Article	O6-alkylguanine-DNA alkyltransferase in cutaneous T-cell lymphoma: implications for treatment with alkylating agents.
Academic Article	Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation.
Academic Article	Inactivation of O6-alkylguanine-DNA alkyltransferase by 8-substituted O6-benzylguanine analogs in mice.
Academic Article	Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates.
Academic Article	Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
Academic Article	Silence is golden: gene hypermethylation and survival in large-cell lymphoma.
Academic Article	Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine.
Academic Article	A phase II trial of oral temozolomide in patients with metastatic renal cell cancer.
Academic Article	Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
Academic Article	Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells.
Academic Article	Temozolomide: realizing the promise and potential.
Academic Article	Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism.
Academic Article	Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
Academic Article	Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
Academic Article	Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene.
Academic Article	Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells.
Academic Article	Molecular mechanisms of resistance and toxicity associated with platinating agents.
Academic Article	Role of O6-alkylguanine-DNA alkyltransferase in protecting against 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-induced long-term toxicities.
Academic Article	Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
Academic Article	Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy.
Academic Article	Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
Academic Article	Identifying genetic variants that contribute to chemotherapy-induced cytotoxicity.
Academic Article	Evaluation of genetic variation contributing to differences in gene expression between populations.
Academic Article	Genetic variants contributing to daunorubicin-induced cytotoxicity.
Academic Article	Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
Academic Article	Role of copper transporters in resistance to platinating agents.
Academic Article	Identification of genetic variants and gene expression relationships associated with pharmacogenes in humans.
Academic Article	Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines.
Academic Article	Identification of common genetic variants that account for transcript isoform variation between human populations.
Academic Article	Identification of genomic regions contributing to etoposide-induced cytotoxicity.
Academic Article	Role of GADD34 in modulation of cisplatin cytotoxicity.
Academic Article	Etoposide pathway.
Academic Article	A pharmacogene database enhanced by the 1000 Genomes Project.
Academic Article	Gene set enrichment analyses revealed differences in gene expression patterns between males and females.
Academic Article	SCAN: SNP and copy number annotation.
Academic Article	Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice.
Academic Article	Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
Academic Article	Identification of genetic variants contributing to cisplatin-induced cytotoxicity by use of a genomewide approach.
Academic Article	The emerging role of microRNAs in drug responses.
Academic Article	Population differences in microRNA expression and biological implications.
Academic Article	Platinum sensitivity-related germline polymorphism discovered via a cell-based approach and analysis of its association with outcome in ovarian cancer patients.
Academic Article	Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress.
Academic Article	Exprtarget: an integrative approach to predicting human microRNA targets.
Academic Article	A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.
Academic Article	Functional consequences of PRPF39 on distant genes and cisplatin sensitivity.
Academic Article	Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans.
Academic Article	Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
Academic Article	Pharmacogenomic discovery using cell-based models.
Academic Article	An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article	Relating human genetic variation to variation in drug responses.
Academic Article	Clinical translation of cell-based pharmacogenomic discovery.
Academic Article	Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
Academic Article	Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL.
Academic Article	Copy number polymorphisms and anticancer pharmacogenomics.
Academic Article	Human liver oxidative metabolism of O6-benzylguanine.
Academic Article	Sequential therapy with dacarbazine and carmustine: a phase I study.
Academic Article	Susceptibility loci involved in cisplatin-induced cytotoxicity and apoptosis.
Academic Article	The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics.
Academic Article	Exploring the evolutionary history of the differentially expressed genes between human populations: action of recent positive selection.
Academic Article	Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article	Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
Academic Article	Comprehensive survey of SNPs in the Affymetrix exon array using the 1000 Genomes dataset.
Academic Article	The use of genomic information to optimize cancer chemotherapy.
Academic Article	Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
Academic Article	Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
Academic Article	Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer.
Academic Article	Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat.
Academic Article	Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
Academic Article	Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals.
Academic Article	A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity.
Academic Article	Mapping genes that contribute to daunorubicin-induced cytotoxicity.
Academic Article	Inhibition of nuclear factor-kappaB activity by temozolomide involves O6-methylguanine induced inhibition of p65 DNA binding.
Academic Article	Approaches to the discovery of pharmacogenomic markers in oncology: 2000-2010-2020.
Academic Article	Germline polymorphisms discovered via a cell-based, genome-wide approach predict platinum response in head and neck cancers.
Academic Article	Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans.
Academic Article	Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.
Academic Article	Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
Academic Article	Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Academic Article	Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
Academic Article	Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents.
Academic Article	Sequence specificity of guanine alkylation and repair.
Academic Article	Intracellular activation of cytotoxic agents: kinetic models for methylnitrosoureas and N-methyl-N'-nitro-N-nitrosoguanidine in cell culture.
Academic Article	Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
Academic Article	Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion.
Academic Article	Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase.
Academic Article	Specificity of O6-alkylguanine-DNA alkyltransferase.
Academic Article	Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli.
Academic Article	Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
Academic Article	An analysis of 1-(2-chloroethyl)-1-nitrosourea activity at the cellular level.
Academic Article	Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.
Academic Article	Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.
Academic Article	Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
Academic Article	Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Academic Article	Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
Academic Article	Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.
Academic Article	Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
Academic Article	Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
Academic Article	Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Academic Article	Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.
Academic Article	Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells.
Academic Article	Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase.
Academic Article	Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli.
Academic Article	Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria.
Academic Article	Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents.
Academic Article	Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine.
Academic Article	The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
Academic Article	Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase.
Academic Article	Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
Academic Article	Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Academic Article	Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase.
Academic Article	8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
Academic Article	Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article	Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
Academic Article	Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene.
Academic Article	O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
Academic Article	Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
Academic Article	The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
Academic Article	Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Academic Article	O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Academic Article	Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Academic Article	Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study.
Academic Article	Somatic acquisition and signaling of TGFBR1*6A in cancer.
Academic Article	Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Academic Article	Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Academic Article	Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
Academic Article	Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Academic Article	O6-methylguanine-DNA methyltransferase activity and promoter methylation status in pediatric rhabdomyosarcoma.
Academic Article	Allelic loss at the GPx-1 locus in cancer of the head and neck.
Academic Article	A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.
Academic Article	Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
Academic Article	Poly(ADP-ribose) polymerase inhibitor ABT-888 potentiates the cytotoxic activity of temozolomide in leukemia cells: influence of mismatch repair status and O6-methylguanine-DNA methyltransferase activity.
Academic Article	Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
Academic Article	Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Academic Article	O6-benzylguanine-mediated enhancement of chemotherapy.
Academic Article	Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial.
Academic Article	Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Academic Article	Genome scan implicates adhesion biological pathways in secondary leukemia.
Academic Article	Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
Academic Article	Genetic variants in cytosolic 5'-nucleotidase II are associated with its expression and cytarabine sensitivity in HapMap cell lines and in patients with acute myeloid leukemia.
Academic Article	Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations.
Academic Article	Mouse models of human AML accurately predict chemotherapy response.
Academic Article	The kinase inhibitor O6-cyclohexylmethylguanine (NU2058) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK2.
Academic Article	Comprehensive genetic analysis of cytarabine sensitivity in a cell-based model identifies polymorphisms associated with outcome in AML patients.
Academic Article	Multicenter phase II trial of temozolomide in mycosis fungoides/sezary syndrome: correlation with O6-methylguanine-DNA methyltransferase and mismatch repair proteins.
Academic Article	Lymphoblastoid cell lines in pharmacogenomics: how applicable are they to clinical outcomes?
Academic Article	Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine.
Academic Article	Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity.
Academic Article	Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
Academic Article	Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
Academic Article	Mechanisms of resistance to the toxicity of cyclophosphamide.
Academic Article	Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
Academic Article	Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.
Academic Article	Trans-population analysis of genetic mechanisms of ethnic disparities in neuroblastoma survival.
Academic Article	Poly-omic prediction of complex traits: OmicKriging.
Academic Article	Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels.
Academic Article	Pharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.
Academic Article	Genetic and epigenetic variants contributing to clofarabine cytotoxicity.
Academic Article	Cell cycle arrest in a model of colistin nephrotoxicity.
Academic Article	Modeling chemotherapeutic neurotoxicity with human induced pluripotent stem cell-derived neuronal cells.
Academic Article	SCAN database: facilitating integrative analyses of cytosine modification and expression QTL.
Academic Article	EPS8 inhibition increases cisplatin sensitivity in lung cancer cells.
Academic Article	The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
Academic Article	Chemotherapy-induced peripheral neurotoxicity and ototoxicity: new paradigms for translational genomics.
Academic Article	Integrating cell-based and clinical genome-wide studies to identify genetic variants contributing to treatment failure in neuroblastoma patients.
Academic Article	RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients.
Academic Article	Hydroxylation and N-dechloroethylation of Ifosfamide and deuterated Ifosfamide by the human cytochrome p450s and their commonly occurring polymorphisms.
Academic Article	Characterization of CpG sites that escape methylation on the inactive human X-chromosome.
Academic Article	Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy.
Academic Article	Chemotherapy-induced peripheral neuropathy: Current status and progress.
Academic Article	Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.
Academic Article	Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
Academic Article	Variants in WFS1 and Other Mendelian Deafness Genes Are Associated with Cisplatin-Associated Ototoxicity.
Academic Article	Clinical and Genome-Wide Analysis of Cisplatin-Induced Peripheral Neuropathy in Survivors of Adult-Onset Cancer.
Academic Article	Racial disparities in omission of oncotype DX but no racial disparities in chemotherapy receipt following completed oncotype DX test results.
Academic Article	Clinical and Genome-wide Analysis of Cisplatin-induced Tinnitus Implicates Novel Ototoxic Mechanisms.
Academic Article	Genomic Variants of Cytarabine Sensitivity Associated with Treatment-Related Mortality in Pediatric AML: A Report from the Children's Oncology Group.
Academic Article	Clinical evaluation of germline polymorphisms associated with capecitabine toxicity in breast cancer: TBCRC-015.
Academic Article	Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors.
Academic Article	Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.
Academic Article	Clinical and genetic risk factors for radiation-associated ototoxicity: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort.
Academic Article	Comprehensive association analysis of speech recognition thresholds after cisplatin-based chemotherapy in survivors of adult-onset cancer.
Academic Article	Prevalence and risk factors for ototoxicity after cisplatin-based chemotherapy.
Concept	Pemetrexed
Concept	Poly(ADP-ribose) Polymerase Inhibitors
Concept	Bevacizumab
Concept	Capecitabine
Concept	Patient Reported Outcome Measures
Concept	Poly (ADP-Ribose) Polymerase-1
Concept	Regulatory Factor X Transcription Factors
Concept	Copper-transporting ATPases
Concept	RUNX1 Translocation Partner 1 Protein
Concept	Patient Outcome Assessment
Concept	Prostatic Neoplasms, Castration-Resistant
Concept	Cytochrome P-450 CYP2C19
Concept	Cytochrome P-450 CYP1B1
Concept	Cytochrome P-450 CYP2B6
Concept	Cytochrome P-450 CYP2C9
Concept	ErbB Receptors

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